Strength Control
You can’t control the amount of strength you apply when using your hands and arms. This results in uncontrolled movements and breaking fragile objects. You have a −(IE) penalty on all Strength and Dexterity checks that require fine motor control, including attack rolls.
Real-world Examples
Amyotrophic Lateral Sclerosis, Ataxia, Multiple Sclerosis, Parkinson’s Disease
Assistive Options
An additional sponge-like grip on handles can help with finger issues. Specialized utensils with long handles or sturdy cups with lids can help with eating. Be creative.
Magical Assistance
The Telekinesis or Mage Hand spells and items that duplicate their effects can assist with this for minor tasks.