Immunocompromised
You have a −(IE) penalty on all saving throws against disease.
Real-world Examples
Addison Disease, Celiac Disease, Dermatomyositis, Graves Disease, Hashimoto Thyroiditis, Multiple Sclerosis, Myasthenia Gravis, Pernicious Anemia, Reactive Arthritis, Rheumatoid Arthritis, Sjögren Syndrome, Systemic Lupus Erythematosus, Diabetes, Down Syndrome
Assistive Options
This is managed by avoiding diseases when possible.
Magical Assistance
Magic that cures diseases can cure a disease once infection happens but cannot be used proactively.